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过去工作提示将吗啡注入中脑导水管周围灰质(PAG)产生的镇痛效果,有可能是兴奋了上行5-HT能神经元作用于伏核而发挥作用。伏核内存在较丰富的阿片受体,后者是否参与达一镇痛过程值得加以探讨。用辐射热甩头测痛,用恒速注射器经慢性埋植不锈钢套管作脑内注射:PAG内1μl/8分钟,伏核1μl/4分钟。 1.伏核内注入纳洛酮对抗PAG内注射吗啡产生的镇痛作用:①30只家兔PAG内洼入吗啡10ug,30分钟时向双侧伏核注入纳洛酮[即(±)纳洛酮]各4μg(n=13),并以(+)纳洛酮4μg(n=8)作为对照。30分钟后测痛,对照组痛阈平均升高135±15％,纳洛酮组仅为41±10％,明显低于对照组(P<0.001)。纳洛酮注入伏核周围的脑区,镇痛效果(104±19％,n=9)与对照组无显著差异。②将注入伏核的纳洛
Past work suggests that the analgesic effect of morphine injection into the periaqueductal gray (PAG) may be excited by the up-going 5-HT neurons acting on the nucleus accumbens. There is abundant opioid receptor in the nucleus accumbens, which is worth discussing whether the latter participates in an analgesic process. With radiant heat shaken head pain, with a constant speed syringe implanted stainless steel cannula for intracerebral injection: PAG 1μl / 8 minutes, nucleus 1μl / 4 minutes. 1. The naloxone injected into the nucleus accumbens against the analgesic effect of morphine injection in PAG: (1) 30 rabbits received 10ug morphine in the depression of the PAG, and naloxone was injected into the bilateral nucleus accumbens at 30 minutes Ketone], 4 μg each (n = 13), and 4 μg naloxone (n = 8) as a control. Thirty minutes later, the pain threshold was increased by 135 ± 15% in the control group and 41 ± 10% in the naloxone group, which was significantly lower than that in the control group (P <0.001). Naloxone injected into the brain around the nucleus accumbens, analgesic effect (104 ± 19%, n = 9) and the control group no significant difference. ② will be injected into the nucleus Naluo