论文部分内容阅读
对自发性高血压大鼠（ＳＨＲ）及正常对照鼠（ＷＫＹ）进行研究。分为ＳＨＲ治疗前、后以及不作治疗组和相应月龄ＷＫＹ５组，其中治疗组给予口服西拉普利３个月。用细胞立体计量检测法测定各组大鼠左心室心肌超微结构的改变，发现（１）ＳＨＲ组除血压高于同龄ＷＫＹ外，存在心肌细胞线粒体密度增高，比表面降低及肌节宽度（Ｚ线长度）延长，肌束及核周水肿，胶原区扩大锌。（２）西拉普利在有效地控制ＳＨＲ的血压的同时能减轻ＳＨＲ的上述心肌超微结构损害。揭示西拉普利能逆转ＳＨＲ心肌超微结构损害，进而逆转左室肥厚及使并发症减少。
Spontaneous hypertensive rats (SHR) and normal control rats (WKY) were studied. Divided into SHR before treatment, after and without treatment group and the corresponding age WKY5 group, in which the treatment group was given oral cilazapril for 3 months. The changes of ultrastructure of left ventricular myocardium in rats in each group were measured by cell stereotaxic assay. The results showed that: (1) In SHR group, the mitochondrial density was increased, the specific surface area was lower and the sarcomere width (Z Line length), muscle bundle and perinuclear edema, collagen area to expand zinc. (2) Cilazapril can effectively reduce the blood pressure of SHR and reduce the above myocardial ultrastructure damage in SHR. It is revealed that Cilazapril can reverse the ultrastructural damage of SHR myocardium and then reverse left ventricular hypertrophy and reduce complications.