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类固醇治疗的并发症是众所周知的,但它在肝功能衰竭病例中可能产生更大的危险性没有被足够认识。本文报告3例皮肤病伴有肝功能衰竭的患者,由于外用类固醇或小剂量全身类固醇治疗发生了严重的副作用。 3例患者年龄在45～55岁之间。前2例曾患有广泛的银屑病,并伴间歇性红皮病,病期分别为30年和8年。对馏油及蒽林不耐受,而外用大量浓的氟化类固醇(每天100克以上),治疗3～4年。例3患顽固性湿疹已12年,对外用类固醇或馏油井无良好效果。该患者在发生股骨头无菌性坏死前,曾服用小剂量倍他米松(0.5毫克,每天2次)6个月。
The complications of steroid therapy are well known, but its potential for greater risk in liver failure cases is not well understood. This article reports three patients with dermatosis and liver failure who have had serious side effects due to topical steroids or low-dose systemic steroids. Three patients were between 45 and 55 years of age. The first two cases had extensive psoriasis with intermittent erythroderma, with a disease duration of 30 years and 8 years, respectively. Paired oil and anthralin intolerance, and external use of a large number of concentrated fluorinated steroids (more than 100 grams per day), the treatment of 3 to 4 years. Case 3 of refractory eczema has been 12 years, external steroids or distillation wells without good results. The patient took a low dose of betamethasone (0.5 mg twice daily) for six months before aseptic necrosis of the femoral head occurred.