红霉素为大环内酯类抗生素的典型代表。但经常使用红霉素,特别是在急性呼吸道疾患时,导致患者分离出高百分率的耐红霉素葡萄球菌菌株。此外,近年来一系列报道认为红霉素碱片剂生物利用度差,这是由于它具有酸不稳定性,而在酸性胃液中发生 Erythromycin is a typical representative of macrolide antibiotics. However, the frequent use of erythromycin, especially in acute respiratory conditions, has led to the isolation of a high percentage of erythromycin resistant Staphylococcus strains in patients. In addition, a series of reports in recent years suggest that erythromycin base tablets have poor bioavailability due to their acid-labile nature that occurs in acidic gastric juices