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目的研究急性脑梗死患者早期神经功能恶化(END)与阿司匹林抵抗(AR)的关系。方法分析2014年9月—2015年12月于湖州市中心医院住院治疗的119例急性脑梗死患者的临床资料,测定血小板聚集功能,评价AR和神经系统功能,采用多因素Logistic回归模型分析END发生的影响因素。结果 119例急性脑梗死患者中发生END 26例,占21.84%。单因素分析显示,在END组患者中有AR、高血压史及糖尿病史者的比例高于非END组(均P<0.05)。多因素分析显示,AR(OR=3.06,95%CI:1.22~7.65)及高血压(OR=3.28,95%CI:1.03~10.53)是急性脑梗死患者发生END的危险因素(均P<0.05)。结论有高血压病史及AR的急性脑梗死患者发生END的风险相对较高。
Objective To study the relationship between early neurological deterioration (END) and aspirin resistance (AR) in patients with acute cerebral infarction. Methods Clinical data of 119 patients with acute cerebral infarction who were hospitalized in Huzhou Central Hospital from September 2014 to December 2015 were analyzed. Platelet aggregation function, AR and nervous system function were evaluated. Multivariate Logistic regression model was used to analyze the occurrence of END The impact of factors. Results Of the 119 patients with acute cerebral infarction, 26 cases occurred, accounting for 21.84%. Univariate analysis showed that the proportion of patients with AR, history of hypertension and diabetes in the END group was higher than that in the non-END group (all P <0.05). Multivariate analysis showed that AR (OR = 3.06, 95% CI: 1.22-7.65) and hypertension (OR = 3.28, 95% CI: 1.03-10.53) were risk factors for END in patients with acute cerebral infarction ). Conclusion There is a relatively high risk of END occurrence in patients with a history of hypertension and AR in acute cerebral infarction.