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衰老和维生素C[VC]缺乏均可导致免疫缺陷。T致裂原刺激人血淋巴细胞增殖反应(PBL)随衰老而减弱,不可能是由PBL亚群消失和血清因子引起,而主要是由至今尚未明来源的细胞间缺陷所致。诸方面获得证据强调VC对其可能有一定影响。血清和组分中VC浓度随衰老而下降,抗坏血酸盐丧失可导致T细胞和吞噬细胞严重减少,但由于补充VC不仅可以矫正这种减少,而用大剂量时却可刺激正常个体T淋巴细胞反应。故作者采用安慰剂
Aging and deficiency of vitamin C [VC] can lead to immunodeficiency. T-stimulated proliferation of pro-inflammatory human blood lymphocytes (PBL) decreased with aging can not be caused by the disappearance of PBL subpopulations and serum factors, but mainly by the so far unknown sources of intercellular defects. Evidence from various sources highlights that VC may have some impact on it. VC concentrations in serum and components decline with aging, and loss of ascorbate results in a severe reduction in T-cells and phagocytes, but not only does this reduction be corrected by the addition of VC, but can be stimulated in large doses by normal individual T-lymphocyte responses . Therefore, the author used placebo