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兔脑缺血３０ｍｉｎ再灌注４５ｍｉｎ后，脑内血栓素Ｂ_２（ＴＸＢ_２）升高和６－酮－前列腺素Ｆ_（１α）（６－酮－ＰＧＦ_（１α））含量降低（Ｐ＜０．０５），血浆和脑环磷酸腺苷（ｃＡＭＰ）含量升高（Ｐ＜０．０１和Ｐ＜０．０５）。于缺血前分别静脉注射黄芪（３．３ｇ／ｋｇ）、活血方（２．５ｇ／ｋｇ）及益气活血方（４．４ｇ／ｋｇ），发现活血方和益气活血方均可抑制再灌注后脑ＴＸＢ_２的升高，提高脑６－酮－ＰＧＦ_（１ａ）含量（Ｐ＜０．０５）。活血方还可抑制脑ｃＡＭＰ的升高（Ｐ＜０．０５），黄芪则对此无明显影响。提示益气活血法通过改善脑局部ＴＸＡ２／ＰＧＩ_２平衡而起作用，主要为活血药物作用。
After cerebral ischemia for 30min and reperfusion for 45min, the levels of TXB_2 and 6-keto-prostaglandin F_(1α) (6-keto-PGF_(1α)) decreased in the brain (P<0.05). Plasma and brain cAMP levels increased (P<0.01 and P<0.05). Intravenous injection of astragalus (3.3g/kg), Huoxue Fang (2.5g/kg) and Yiqi Huoxue Fang (4.4g/kg) were given intravenously before ischemia. It was found that both Huoxue Fang and Yiqi Huoxue Decoction can inhibit further The increase of brain TXB_2 after infusion increased brain 6-keto-PGF_(1a) content (P<0.05). Huoxue Fang also inhibited the elevation of cerebral cAMP (P<0.05), while Huangqi had no significant effect on this. It is suggested that the Qi-invigorating and blood-activating method works by improving the balance of TXA2/PGI2 in the brain, and it mainly acts as a blood-activating drug.