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氟哌啶醇癸酸酯为一新型长效抗精神病药物,其叔醇酯化的立体结构使其化学稳定性良好,临床用其植物油溶剂每4wk一次肌注,3-8mo达到稳态血浓度,无积蓄作用。对情感淡漠、行为退缩、幻觉的疗效肯定,总疗效优于或不亚于其他长效制剂。副作用较轻,锥体外系副反应与一般抗精神病药物相仿。没有发现长期使用致脑损伤的证据。故认为该药为一安全有效的长效抗精神病药物。
Haloperidol capric acid ester is a new long-acting antipsychotic drugs, tertiary alcohol esterified three-dimensional structure to make it good chemical stability, the clinical use of its vegetable oil solvent once every 4wk intramuscular, 3-8mo reach steady state blood concentration , No savings effect. Indifference to emotion, behavior withdrawal, the efficacy of hallucinatory affirmation, the overall effect is better than or no less than other long-acting preparations. Side effects of light, extrapyramidal side effects and general antipsychotic similar. No evidence of long-term use of brain damage was found. Therefore, the drug is considered as a safe and effective long-acting antipsychotic drug.