目的　探讨新生儿缺氧缺血性脑病 (HIE)氢质子磁共振波谱 (1HMRS)检查乳酸及血糖变化。方法　HIE组 10例 ,对照组 8例。1HMRS测定乳酸 (Lac)等代谢产物 ,试纸法测血糖。结果　HIE患儿可见Lac波峰增高 ,出现双峰 ,对照组新生儿Lac波峰不明显或轻度升高 ,两组比较有显著性差异 (P <0 0 1)。HIE组入院时血糖异常比例明显高于对照组。结论　HIE患儿脑Lac水平明显升高 ,血糖异常发生率亦增高 Objective To investigate the changes of lactate and blood glucose in neonates with hypoxic-ischemic encephalopathy (HIE) by proton magnetic resonance spectroscopy (1HMRS). Methods 10 cases of HIE group and 8 cases of control group. 1H MRS determination of lactate (Lac) and other metabolites, test paper method to measure blood sugar. Results The peak of Lac peak appeared in HIE patients with double peaks. The Lac peak in control group was not obvious or mildly elevated. There was a significant difference between the two groups (P <0.01). HIE group admission blood glucose was significantly higher than the control group. Conclusions The level of Lac in brain of HIE children is obviously increased, and the incidence of abnormal blood sugar is also increased