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有文献报告雄兔每天口服5mgSTS557,用药8周能降低雄性家兔的精子活力和减少精液中的果糖含量而导致不育。也有人观察到 STS557能抑制杂种雄性小鼠的生育力。本文报告 STS557对大鼠精子的活力、受精能力以及生殖器官的影响。本实验采用250～300g 的成熟 Holtzman 系雄性大鼠24只,分为三组,每组8只。第1、2组每日皮下分别注射1mg 与0.5mg 的 STS557橄榄油悬液,用药3周;第3组注射等量橄榄油为对照。末次给药后处死动物,用0.9%生理盐水清洗左侧附睾各段,漫于 Hank’s 溶液内捣碎,使精子全部释出,并
There are reports of male rabbits oral administration of 5mgSTS557 daily for 8 weeks can reduce the sperm motility in male rabbits and reduce the fructose content in semen resulting in infertility. It has also been observed that STS557 can inhibit the fertility of hybrid male mice. This article reports the effects of STS557 on sperm motility, fertility and reproductive organs in rats. Twenty-four male Holtzman rats, 250-300g, were divided into three groups of 8 rats each. Groups 1 and 2 were subcutaneously injected with 1 mg and 0.5 mg of STS557 olive oil daily for 3 weeks. Group 3 received the same amount of olive oil as control. After the last administration, the animals were sacrificed, the left epididymis segments were washed with 0.9% physiological saline, diffused in Hank’s solution, and all the sperm were released