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为了研究强的松龙对HBsAg阳性的慢性活动性肝炎(简称CAH)的效用,作者进行了一项随机、设对照的前瞻性临床研究。作者将51例HBsAg阳性的CAH患者按年龄、性别及转氨酶值随机分为强的松龙组和对照组。强的松龙组25例,治疗开始时给予强的松龙15～20mg/日,缓解后减量,维持量为10mg/日。对照组26例,给予安慰剂维生素C150～200mg/日。对两组患者均进行随访检查,治疗开始后第一个月每周随访一次,以后11个月每月随访一次,再往后每2个月随访一次。随访结果表明:在开始治疗后,两组患者的SGPT和SGOT均下降,但转氨酶值在强的松龙组一直保持较高,两组转氨酶值的
In order to investigate the utility of prednisolone against HBsAg-positive chronic active hepatitis (CAH), we conducted a randomized, controlled prospective clinical study. 51 patients with HBsAg-positive CAH patients were randomly divided into prednisolone group and control group according to age, sex and aminotransferase value. Prednisolone group 25 cases, the beginning of treatment given prednisolone 15 ~ 20mg / day, remission after reduction, the maintenance dose of 10mg / day. Control group, 26 cases, placebo vitamin C150 ~ 200mg / day. The patients in both groups were followed up. The patients were followed up once a week in the first month after the start of treatment. The patients were followed up every 11 months and then followed up every 2 months. The follow-up results showed that SGPT and SGOT decreased in both groups after starting treatment, but the transaminase values in the prednisolone group remained high. The transaminase values