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作者采取随机双盲试验,对23例用脂质体佐剂和26例用对照亚病毒疫苗免疫后的老年人进行观察对照,评估了老年人对脂质体佐剂流感A病毒疫苗的细胞毒T淋巴细胞(CTL)反应。材料与方法脂质体佐剂和对照亚病毒疫苗,均为单价并含纯化区带,即含流感A/台湾/1/86(H1N1)病毒。每剂疫苗(0.5ml)含15μg病毒血凝素。脂质体是0.2μm少层状磷脂囊,用二肉豆蔻基磷脂胆碱和胆固醇制备,含42％士4％血凝素。对老年人的脂质体佐剂疫苗反应原性和免疫原性作评价;77例健康志愿者,年龄≥65(77士7)岁,
The authors conducted a randomized, double-blind trial comparing 23 elderly patients immunized with a liposomal adjuvant with 26 control subviral vaccines to assess the effect of the elderly on cytotoxicity of the liposomal adjuvanted influenza A virus vaccine T lymphocyte (CTL) reaction. MATERIALS AND METHODS Liposome adjuvants and control subviral vaccines, both monovalent and containing purified bands, were influenza A / Taiwan / 1/86 (H1N1) virus. Each dose of vaccine (0.5 ml) contains 15 μg of viral hemagglutinin. Liposomes are 0.2 [mu] m lamellar phospholipid vesicles prepared with dimyristylphospholipid choline and cholesterol containing 42% of 4% hemagglutinin. The reactivity and immunogenicity of the liposomal adjuvant vaccine for the elderly were evaluated; 77 healthy volunteers, aged ≥65 (77 ± 7) years old,