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干扰素 (interferon ,IFN)是人体受到病毒或双股RNA刺激物的刺激产生免疫应答 ,由细胞合成及分泌的一族蛋白质类 ,可作用于其它细胞干扰病毒的复制。 1 95 7年Isaacs和Lindenmann发现IFN并证实其有抗病毒活性 ,近来还发现IFN具有抑制某些细胞生长、免疫调节 抑制和杀伤肿瘤细胞、影响细胞分化和机体的发育等作用。目前IFN是国内外慢性乙型肝炎与丙型肝炎抗病毒治疗主要药物 ,然而慢性乙肝患者采用IFN治疗后出现持续性反应率不高 ,HBeAg阴转率约为30 % [1 ] ,IFN与利巴韦林联合治疗慢性丙型肝炎持续反应率也仅仅约为 5 4 %～ 5 6 % [2 ] 。IFN疗效主要和机体免疫耐受、病毒基因变异、细胞内病毒基因整合、IFN抗体产生等有关 ,IFN抵抗 (IFNresis tance)出现的原因包括了宿主、病毒和IFN三方面因素 ,目前IFN抵抗的机制尚未完全明了。
Interferon (IFN) is a family of proteins that are stimulated by viral or double-stranded RNA stimulants and synthesized and secreted by cells. They can act on other cells to interfere with virus replication. In 1957, Isaacs and Lindenmann found IFN and confirmed its antiviral activity. Recently, it has also been found that IFN can inhibit the growth of certain cells, inhibit and kill immunosuppressive tumor cells, and affect cell differentiation and development of the body. At present, IFN is the main drug of chronic hepatitis B and hepatitis C antiviral therapy both at home and abroad. However, the persistent response rate of patients with chronic hepatitis B after IFN therapy is not high, and the negative conversion rate of HBeAg is about 30% [1] The continuous response rate of ribavirin combined treatment of chronic hepatitis C is only about 54% ~ 56% [2]. The main therapeutic effect of IFN is related to immune tolerance, viral gene variation, intracellular viral gene integration and IFN antibody production. The causes of IFN resistance include three aspects of host, virus and IFN, and the current mechanisms of IFN resistance Not yet fully understood.