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人的胎盘中含有多种垂体样激素,如绒毛膜促性腺激素、绒毛膜促甲状腺激素和绒毛膜促肾上腺皮质激素。设想这些激素在调节胎儿正常发育和调节胎盘内分泌机能中具有重要作用。最近,加拿大的Lemaire等,用放射免疫法及大鼠脑匀浆中~3H标记的纳洛酮受体替换法证明,人的胎盘中还存在强啡肽(dynorph-in)。用上述方法测定的结果,每1克胎盘中含有57.6pmol的强啡胜和134.4pmol纳洛酮受体当量,这一数值可与脑和垂体中的含量相比拟。将胎盘提取液经葡聚糖G-50层析的结果还表示,其洗脱峰主要有二个,一个与强啡肽洗脱部位一致;另一个与合成的β-内啡肽一致,表明人胎盘中内源性阿片样物质的主要存在形式为强啡肽和β-内啡肽。但作者指出,这并不排除在特殊生理条件下或某些胎盘细胞,可产生脑啡肽或
Human placenta contains a variety of pituitary-like hormones, such as chorionic gonadotropin, chorionic thyroid stimulating hormone and chorionic adrenocorticotropic hormone. It is envisaged that these hormones play an important role in regulating the normal development of the fetus and regulating the endocrine function of the placenta. More recently, Lemaire et al. In Canada demonstrated that dynorphin is also present in human placenta by radioimmunoassay and ~ 3H labeling of naloxone receptor replacement in rat brain homogenates. As a result of the above-mentioned method, there were 57.6 pmol of potent phenylephrine and 134.4 pmol of naloxone receptor equivalent per 1 g of placenta, comparable to those in brain and pituitary gland. The results of the placental extract by G-50 dextran also showed that there are two main elution peaks, one is consistent with the elution site of dynorphin; the other is consistent with the synthesized beta-endorphin, indicating The main forms of endogenous opioids in human placenta are dynorphin and β-endorphin. However, the authors point out that this does not preclude the use of enkephalins or certain placental cells under specific physiological conditions or