论文部分内容阅读
提出了基于浮动基准位置的参考测量方法,有望实现血糖浓度的在体相对测量。基于定态漫射方程在半无限介质中的解析解,分析了浮动基准位置满足的函数关系式;基于Monte Carlo模拟方法,考察了三层皮肤模型在1000~1400nm波段内浮动基准位置的分布情况,同时分析了吸收系数和散射系数、表皮层和真皮层厚度对浮动基准位置的影响;搭建了基于超辐射发光二极管光源的多环光纤束检测系统,初步验证了浮动基准位置在人体中的存在性。模拟结果表明,三层皮肤模型在1000~1400nm波段内存在浮动基准位置且具有波长特性,散射系数变化对基准位置的影响大于吸收系数,表皮层厚度差异的影响大于真皮层。三位志愿者的在体实验表明,人体手掌在1050、1219、1314nm处均存在浮动基准位置,位于径向检测距离1.25~1.75mm之间,实验结果小于模拟结果,最大偏差达0.75mm。该结果对指导浮动基准测量光纤探头的设计具有一定参考价值。
A reference measurement method based on floating reference position is proposed, which is expected to realize in-vivo relative measurement of blood glucose concentration. Based on the analytic solution of the stationary diffusion equation in semi-infinite medium, the functional relation of the floating reference position is analyzed. Based on the Monte Carlo simulation, the distribution of the floating reference position in the three-layer skin model in 1000 ~ 1400 nm band is investigated The effects of absorption coefficient and scattering coefficient, epidermis and dermis thickness on the floating reference position were also analyzed. A multi-ring fiber bundle detection system based on the superluminescent diode light source was set up to verify the existence of floating reference position in the human body Sex. The simulation results show that the three-layer skin model has a floating reference position and a wavelength characteristic in the wavelength band of 1000-1400 nm. The influence of the variation of the scattering coefficient on the reference position is greater than the absorption coefficient, and the difference of the epidermis layer thickness is greater than that of the dermis layer. In-vivo experiments of three volunteers showed that the human palms had floating reference positions at 1050, 1219 and 1314 nm, located between the radial detection distances of 1.25 and 1.75 mm. The experimental results were less than the simulation results and the maximum deviation was 0.75 mm. The result has certain reference value for guiding the design of floating reference measurement fiber probe.