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目的 :观察老年糖尿病患者用复方丹参静滴后 ,其超氧化物歧化酶 (SOD)活力和血液流变学的变化 ,并探讨该药物在老年糖尿病并发症防治中的作用。方法 :将 98例老年糖尿病患者随机分为治疗组和对照组 ,治疗组用复方丹参注射液加入 0 .9%氯化钠静滴 ,对照组用 0 .9%氯化钠静滴 ,观察治疗前和治疗 30天后两组病人的SOD及血液流变学等指标的变化。结果 :复方丹参组病人治疗后的SOD、糖化血红蛋白 (HBAlc)、纤维蛋白原含量、全血及血浆粘度、红细胞电泳时间、空腹血糖均较治疗前有明显改善 (P <0 .0 1) ,与对照组相比 ,有非常显著的差异 (P <0 .0 1)。结论 :复方丹参能够提高患者体内SOD含量 ,清除自由基 ,保护组织细胞及功能 ,改善老年糖尿病患者血液流变学特征 ,在老年糖尿病治疗和慢性并发症的防治中有一定的独特作用
OBJECTIVE: To observe the changes of superoxide dismutase (SOD) activity and hemorheology in senile patients with diabetes mellitus after intravenous infusion of compound Salvia miltiorrhiza and to explore the role of the drug in preventing and treating the complications of senile diabetes. Methods: 98 cases of elderly diabetic patients were randomly divided into treatment group and control group, the treatment group with compound Danshen injection 0.9% sodium chloride intravenous infusion, the control group with 0.9% sodium chloride intravenous infusion, observation and treatment Before and 30 days after treatment, the changes of SOD and hemorheology in two groups of patients were observed. Results: The SOD, HbAlc, fibrinogen, whole blood and plasma viscosity, erythrocyte electrophoresis time and fasting blood glucose in the compound Danshen group were significantly improved after treatment (P <0.01) Compared with the control group, there is a very significant difference (P <0.01). Conclusion: Salvia miltiorrhiza can improve the content of SOD, scavenge free radicals, protect the cells and function of the body, improve the hemorheological characteristics of elderly patients with diabetes, and have some unique roles in the prevention and treatment of diabetes mellitus and chronic complications in the elderly