脑立体定向手术非直视下操作，术中可能损伤深部脑血管而致颅内出血。特别是小动脉出血，处理困难。本文报告凝血酶脑内局部灌注治疗走向术中出血１０例，包括动脉出血２例。控制出血快速有效，无并发症。尽管凝血酶用量过多可造成脑血管痉挛和脑梗塞，但只要用量适当则可有效止血，挽救生命，故局部灌注适量凝血酶的方法是可取的。 Stereotactic brain surgery under non-direct vision, surgery may damage deep cerebral blood vessels caused by intracranial hemorrhage. In particular, small arteries bleeding, handling difficulties. This article reports thrombin intracerebral perfusion treatment to intraoperative bleeding in 10 cases, including 2 cases of arterial bleeding. Quick and effective control of bleeding, no complications. Although excessive use of thrombin can cause cerebral vasospasm and cerebral infarction, as long as the appropriate amount can effectively stop bleeding and save lives, it is advisable to locally administer appropriate amount of thrombin.