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目的观察老年急性心肌梗死患者中性粒细胞表面黏附分子L-selectin和CD11b的表达以及溶栓治疗对其影响。方法用免疫荧光技术和流式细胞术测定30例正常对照组和32例老年急性心肌梗死患者溶栓前后中性粒细胞表面黏附分子L-selectin和CD11b的表达。结果与对照组相比,急性心肌梗死患者中性粒细胞L-selectin的表达下降47.3%(P<0.01),而CD11b的表达升高145.5%(P<0.01)。溶栓治疗前后中性粒细胞L-selectin和CD11b的表达无明显变化。结论老年急性心肌梗死患者中性粒细胞L-selectin表达下调,CD11b表达上调,提示中性粒细胞被激活。溶栓治疗对中性粒细胞表面黏附分子的表达无影响。
Objective To investigate the expression of L-selectin and CD11b on neutrophils in elderly patients with acute myocardial infarction and the effect of thrombolytic therapy on it. Methods The expressions of L-selectin and CD11b on neutrophils were measured by immunofluorescence and flow cytometry before and after thrombolysis in 30 normal controls and 32 elderly patients with acute myocardial infarction. Results Compared with the control group, the expression of L-selectin in neutrophils was decreased by 47.3% (P <0.01) and the expression of CD11b was increased by 145.5% (P <0.01) in patients with acute myocardial infarction. Neutrophil L-selectin and CD11b expression before and after thrombolysis did not change significantly. Conclusion The expression of L-selectin in neutrophils is down-regulated and the expression of CD11b is up-regulated in elderly patients with acute myocardial infarction, suggesting that neutrophils are activated. Thrombolytic therapy had no effect on the expression of neutrophil surface adhesion molecules.