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目的:综合分析幽门螺杆菌(Hp)感染与小儿再发性腹痛(RAP)的关系。方法:计算机检索1999年9月至2009年9月国内外期刊网数据库,纳入Hp感染与小儿再发性腹痛关系的病例-对照研究,用Meta分析方法对数据进行处理,估计其综合OR值和95%CI。结果:共纳入23篇文献,包括3 496例病例组和2 487例对照组。Meta分析显示Hp感染与小儿再发性腹痛的关联性有统计学意义[OR合并=2.65,95%CI(2.05,3.43)];Hp感染与RAP患儿年龄的关联性有统计学意义[OR合并=0.71,95%CI(0.52,0.97)];与RAP患儿的性别及父母文化程度的关联性则无统计学意义,其OR合并分别是1.05,1.18,95%CI分别是(0.84,1.32),(0.73,1.90);Hp根治与RAP患儿腹痛缓解的关联性有统计学意义[OR合并=16.65,95%CI(10.01,27.69)]。结论:Hp感染是小儿再发性腹痛发生的重要危险因素之一。年龄较大的儿童更容易因Hp感染导致腹痛。Hp根除治疗可以显著缓解部分再发性腹痛患儿的腹痛症状。
Objective: To analyze the relationship between Helicobacter pylori (Hp) infection and recurrent abdominal pain (RAP) in children. METHODS: A computer-based online-to-internet database was searched from September 1999 to September 2009, and a case-control study was conducted to investigate the relationship between Hp infection and recurrent abdominal pain in children. Meta-analysis was used to analyze the data. The combined OR and 95% CI. RESULTS: Twenty-three articles were included, including 3 496 cases and 2 487 controls. Meta-analysis showed that the correlation between Hp infection and recurrent abdominal pain was statistically significant (OR = 2.65, 95% CI (2.05, 3.43)]. The correlation between Hp infection and age of children with RAP was statistically significant (0.92, 95% CI (0.52,0.97)]. There was no significant correlation between gender and parental education in children with RAP (OR = 1.05, 1.18, 95% CI, 1.32), (0.73,1.90). The correlation between Hp radical and abdominal pain relief in children with RAP was statistically significant (OR = 16.65, 95% CI: 10.01, 27.69). Conclusion: Hp infection is one of the important risk factors of recurrent abdominal pain in children. Older children are more susceptible to abdominal pain due to Hp infection. Hp eradication therapy can significantly alleviate the symptoms of abdominal pain in children with partial recurrent abdominal pain.