论文部分内容阅读
本文用活跃病区水、粮喂养了15只恒河幼猴复制出了类似人的大骨节病的生化和病理改变。初步认为:(1)只要选择敏感动物,又确系采用带有致病因子的水粮,大骨节病的动物模型是可能复制的。(2)本病的致病因子和主要条件因子既存在于病区粮中,也存在于水中。(3)低硒可出现体内血尿等一系列生化学改变,但与软骨坏死并不一致。(4)硒对动物的软骨坏死有一定的保护作用,但硒的高低与软骨坏死关系还有待进一步研究。
In this paper, active ward water, food, feeding 15 Ganges baby monkeys reproduce a similar human Kashin-Beck disease biochemical and pathological changes. Preliminary thought: (1) As long as the choice of sensitive animals, and indeed with the use of water-soluble dietary pathogenic factors, Kashin-Beck disease animal model may be replicated. (2) The pathogenic factors of the disease and the main conditions of both existing in the ward food, but also in the water. (3) low selenium may occur a series of biochemical changes in body hematuria, but not consistent with cartilage necrosis. (4) Selenium has a certain protective effect on animal’s cartilage necrosis, but the relationship between selenium level and cartilage necrosis remains to be further studied.