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目的探讨血浆可溶性髓样细胞触发受体-1(soluble triggering receptor expressed on myeloid cells-1,sTREM-1)评估脓毒性休克患者预后的价值。方法 42例脓毒性休克患者均给予集束化治疗,28d后存活33例为生存组,死亡9例为死亡组,检测并比较2组入住ICU第1、3、5天血浆sTREM-1水平,急性生理和慢性健康评分Ⅱ(Acute Physiology and Chronic Health EvaluationⅡ,APACHEⅡ)及全身感染相关性器官功能衰竭评分(Sepsis-related Organ Failure Assessment,SOFA),分析sTREM-1水平与APACHEⅡ、SOFA评分的相关性。结果死亡组入住ICU第3、5天血浆sTREM-1水平[(568.49±46.02)、(603.58±28.82)ng/L]、APACHEⅡ评分(34.50±4.46、38.37±4.39)、SOFA评分(14.64±3.97、18.15±3.84)高于生存组[血浆sTREM-1(396.11±27.05)、(172.58±13.32)ng/L,APACHEⅡ评分24.59±5.86、15.46±6.67,SOFA评分10.21±1.85、6.98±2.10](P<0.05);Spearman相关分析结果显示,血浆sTREM-1水平与APACHEⅡ评分(r=0.472,P=0.033)、SOFA评分(r=0.528,P=0.005)呈正相关。结论血浆sTREM-1水平可用于脓毒性休克患者预后的评估。
Objective To investigate the value of plasma soluble myeloid cell-1 (sTREM-1) in evaluating the prognosis of patients with septic shock. Methods Twenty-four patients with septic shock received cluster therapy. After 28 days, 33 survived and 9 died. The levels of plasma sTREM-1 in the first, third, fifth day of ICU were detected and compared in both groups. Acute The correlation between sTREM-1 level and APACHEⅡ, SOFA scores was analyzed by using Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) and the Sepsis-related Organ Failure Assessment (SOFA). Results The plasma levels of sTREM-1 in the death group ([568.49 ± 46.02], (603.58 ± 28.82) ng / L], APACHEⅡscore (34.50 ± 4.46, 38.37 ± 4.39) and SOFA (14.64 ± 3.97 , 18.15 ± 3.84) were higher than those in the survival group [plasma sTREM-1 (396.11 ± 27.05), (172.58 ± 13.32) ng / L, APACHEⅡscore 24.59 ± 5.86,15.46 ± 6.67, SOFA score 10.21 ± 1.85,6.98 ± 2.10] P <0.05). Spearman correlation analysis showed that plasma sTREM-1 level was positively correlated with APACHEⅡscore (r = 0.472, P = 0.033) and SOFA score (r = 0.528, P = 0.005). Conclusion Plasma sTREM-1 level can be used to evaluate the prognosis of patients with septic shock.