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通过显微图像分析仪对60例胃高、中、低分化腺癌和10例胃腺癌的淋巴结转移灶共1050个随机视野中肿瘤细胞进行DNA倍体分析,发现腺癌细胞DNA倍体组成和其不同分化程度间存在一定相关性,其中在所有已发生了淋巴结转移的病例中,肿瘤细胞DNA倍体中＞5C(C为倍体)所占的比例绝大部分明显高于未发生淋巴结转移者,且接近于腺癌淋巴结转移灶中肿瘤细胞的DNA倍体＞5C的比例,两者之间存在的相关性值得进一步分析探讨。同时,这一特征变化是否也存在于其他恶性肿瘤的DNA倍体组成比例中,以及是否能应用为判断肿瘤淋巴结转移与否的参考指标值得深入研究;另外,由于显微图像分析仪相对于其他检测肿瘤细胞DNA含量和倍体分析的方法具有其特别的优点,值得推广。
The DNA ploidy analysis of tumor cells in 1050 random fields of lymph node metastases in 60 cases of high, middle and poorly differentiated gastric adenocarcinoma and 10 cases of gastric adenocarcinoma was performed by microscopic image analyzer. There is a certain correlation between the different degrees of differentiation. Among all cases with lymph node metastasis, the proportion of >5C (C is ploidy) in DNA ploidy of tumor cells is significantly higher than that of no lymph node metastasis. The correlation between the DNA ploidy and the 5C ratio of tumor cells in adenocarcinoma lymph node metastases is worthy of further analysis. At the same time, whether this characteristic change is also present in the proportion of DNA ploidy in other malignancies, and whether it can be used as a reference index for judging lymph node metastasis or not is worthy of in-depth study; in addition, due to microscopic image analyzer compared to other The method of detecting DNA content of tumor cells and ploidy analysis has its special advantages and is worthy of promotion.