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Nefopam是一种新的、结构上与吗啡、哌(口替)啶和镇痛新等苯并吗啡烷类镇痛药完全不同的化合物。短期临床研究表明,它对术后疼痛有效,20mg的nefopam相当于5～12mg的硫酸吗啡。Nefopam没有苯并吗啡烷类药物的不良反应如成瘾性和呼吸抑制。长期安全性试验证实,健康受试者未产生成瘾性或耐受现象,在医嘱剂量下亦未见呼吸抑制。在上述研究的基础上,作者进行了盐酸nefopam、硫酸吗啡、镇痛新和哌(口替)啶的双盲比较试验,以确定nefopam是否能作为术后镇痛
Nefopam is a new compound that is completely different in structure from morphinan, piperidine and analgesic benzalkonium analgesics. Short-term clinical studies have shown that it is effective in postoperative pain, 20mg of nefopam is equivalent to 5 ~ 12mg of morphine sulfate. Nefopam has no side effects of benz morphine drugs such as addiction and respiratory depression. Long-term safety tests confirmed that healthy subjects did not produce addictive or tolerant phenomenon, and no respiratory depression was observed at the dosage of the doctor’s advice. Based on the above studies, the authors conducted a double-blind comparative trial of nefopam hydrochloride, morphine sulfate, neoadjuvant and piperidine (oral) to determine whether nefopam can be used as a postoperative analgesic