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目的:观察曲美他嗪联合阿托伐他汀钙治疗不稳定型心绞痛(UA)的临床疗效。方法:将152例UA患者随机分成两组,治疗组78例,对照组74例。对照组给予硝酸酯类、β受体阻滞剂等常规治疗。治疗组在常规治疗的基础上加用曲美他嗪20mg,3次/d;阿托伐他汀钙10mg,1次/d,睡前口服,连服6周,疗程结束后观察心绞痛控制情况及血清中总胆固醇(TC)和甘油三脂(TG)及低密度脂蛋白(LDL-C)变化并与对照组比较。结果:治疗组用药后TC和TG及LDL-C明显下降。治疗组的心绞痛控制情况也明显优于对照组(P<0.05)。结论:曲美他嗪、阿托伐他汀钙联合治疗UA效果好,不良反应少。
Objective: To observe the clinical efficacy of trimetazidine combined with atorvastatin calcium in the treatment of unstable angina pectoris (UA). Methods: 152 patients with UA were randomly divided into two groups, 78 cases in the treatment group and 74 cases in the control group. The control group was given nitrates, β-blockers and other conventional treatment. The treatment group was treated with trimetazidine 20 mg three times a day on the basis of routine treatment. Atorvastatin calcium 10 mg once a day was orally administered at bedtime for 6 weeks. After the treatment, angina pectoris was observed. Serum total cholesterol (TC) and triglyceride (TG) and low density lipoprotein (LDL-C) changes and compared with the control group. Results: TC and TG and LDL-C in treatment group decreased significantly. Angina pectoris control group also significantly better than the control group (P <0.05). Conclusion: Trimetazidine and atorvastatin combined with calcium have a good effect and little side effects.