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维生素A衍生物很多,本文仅报道全反式维生素A酸,异维A酸、芳香维A酸的最近临床进展。 1.全反式维生素A酸又名维A酸、维甲酸、Tretinoin等。美国药典第23版(1995年)收载。国内上海第六制药厂生产(沪卫药准字(81)第968号)。本药适应证为:对癌前期病变有治疗作用;可防治化学诱发的动物肺癌、乳腺癌、膀胱癌,胃癌、宫颈癌等。另外,治疗痤疮、皮癣,粉刺,皮肤皱裂等。 (1)全反式维A酸治疗急性早幼粒细胞白血病: 急性早幼粒细胞白血病(APL)是急性白血病的一种类型,常规化疗诱导缓解期,常发
Vitamin A derivatives are many, this article only reported the recent clinical progress of all-trans retinoic acid, isotretinoin, aromatic Victoria A acid. 1. All-trans retinoic acid, also known as Victoria A acid, retinoic acid, Tretinoin and so on. American Pharmacopoeia 23rd Edition (1995). Domestic production of the sixth Shanghai Pharmaceutical Factory (Shanghai Wei medicine accurate character (81) No. 968). Indications for the drug: Pre-cancerous lesions have a therapeutic effect; can prevent chemical-induced animal lung cancer, breast cancer, bladder cancer, stomach cancer, cervical cancer and so on. In addition, the treatment of acne, psoriasis, acne, skin folds and so on. (1) All-trans retinoic acid treatment of acute promyelocytic leukemia: acute promyelocytic leukemia (APL) is a type of acute leukemia, conventional chemotherapy-induced remission, often