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临床实践及动物实验均表明ＶｉｔＫ３有镇痛作用。本实验发现ＶｉｔＫ３（６４ｍｇ·ｋｇ－１．ｉｐ）急性用药可使Ｗｉｓｔａｒ大白鼠脑内亮氨酸脑啡肽含量在尾壳核升高４３％（Ｐ＜０．０１）．在下丘脑升高４５％（Ｐ＜０．０５）。ＶｉｔＫ３（１．９６×１０－５～６．２９×１０－４ｍｏｌ．Ｌ－１）剂量依赖性地部分抑制低频电刺激引起的豚鼠回肠收缩，其效价约为吗啡的１／５０００。上述结果提示ＶｉｔＫ３的中枢镇痛作用可能与某些脑区内脑啡肽增多有关。
Clinical practice and animal experiments have shown that VitK3 has analgesic effect. The experiment found that the acute administration of VitK3 (64mg · kg-1.ip) could increase the content of leucine enkephalin in the caudate putamen by 43% (P <0.01). In the hypothalamus increased 45% (P <0.05). VitK3 (1.96 × 10-5 ~ 6.29 × 10-4mol.L-1) partially inhibited the ileal contraction of guinea pigs induced by low-frequency electrical stimulation dose-dependently, which was about 1/5000 of that of morphine. The above results suggest that the central analgesic effect of VitK3 may be related to the increase of enkephalins in some brain regions.