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目的观察炎琥宁对儿童哮喘的临床疗效及机制研究。方法共计105例支气管哮喘患儿纳入研究,并随机分为两组:对照组(n=42)与干预组(n=63)。所有患儿均接受规范性治疗。干预组在治疗基础上加用炎琥宁雾化吸入。记录两组症状体征、肺功能(FEV1、PEF)并测定两组血清中免疫球蛋白(IgA、IgM、IgG、IgE)水平。结果两组总有效率均为90.5%;接受治疗后,两组在肺功能改善上未显现出差异性,但炎琥宁可以更快地改善肺部症状与体征(P<0.05),并能显著升高IgA、IgG而降低IgE,提高患儿免疫力(P<0.05);雾化吸入炎琥宁未见不良反应。结论炎琥宁雾化吸入对肺功能影响不大,但可改善肺部症状与体征,提高患儿免疫力,无不良反应。
Objective To observe the clinical efficacy and mechanism of Yanhu Ning on childhood asthma. Methods A total of 105 children with bronchial asthma were enrolled and randomly divided into two groups: control group (n = 42) and intervention group (n = 63). All children received normative treatment. Intervention group on the basis of treatment with Yanhuning inhalation. Two groups of symptoms and signs and pulmonary function (FEV1, PEF) were recorded and the serum immunoglobulin (IgA, IgM, IgG, IgE) levels were measured. Results The total effective rate was 90.5% in both groups. After treatment, there was no significant difference between the two groups in improving pulmonary function, but Yanhu Ning could improve the symptoms and signs of lungs more quickly (P <0.05) Increased IgA, IgG and lower IgE, improve immunity in children (P <0.05); inhalation of Yan Hu Ning no adverse reactions. Conclusion Yanhuoning inhalation on lung function has little effect, but can improve lung symptoms and signs, improve children’s immunity, no adverse reactions.