理想的给药方案应建立在时程药效的连续测量上。本文从药效指标的选择、药效测量方法的标准化、临床药效学在给药方案设计中的应用等方面,阐述了药效与易测体液药物浓度之间及药效与效应室药物浓度之间的关系、药功学/药效结合模型在药效学研究中的应用。 The ideal dosing regimen should be based on the continuous measurement of time course efficacy. In this paper, the choice of pharmacodynamic indicators, the standardization of efficacy measurement methods, the clinical pharmacodynamics in the design of drug delivery programs and other aspects, elaborated the efficacy and easy to measure the concentration of drug concentration and drug efficacy and effect room drug concentration The relationship between pharmacodynamics / pharmacodynamics model in the application of pharmacodynamics.