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在含碘量相等的情况下,经静脉注射非离子型的、低渗透性造影剂 Iopamidol(本文简称 Iop)与通常应用的 Meglumin-Ioglicinat(本文简称 M-Iog)相比,很少导致血清中的组织胺浓度增高。据统计表明,在注射离子型造影剂后3～5分钟,血清中组织胺的平均浓度值较注射非离子型造影剂为高。此观察结果与应用 Iop 后,其类变态反应性和类过敏性副作用较少的情况相符合。目前尚不能由统计学明确说明,是否由此就可以使此类罕见的威胁生命的并发症减少。主要是对曾有造影剂过敏和变态反应病史的患者应用非离子型的、低渗透性造影剂可减少并发症的发生。
Intravenous injection of Iopamidol, a non-ionic, low-permeability contrast agent (referred to as Iop for short) compared to commonly used Meglumin-Ioglicinat (herein referred to as M-Iog) Histamine concentration increased. According to statistics, in 3 to 5 minutes after the injection of ionic contrast agent, the average concentration of histamine in serum is higher than that of nonionic contrast agent. This observation is consistent with the less severe allergic and allergic side effects after Iop application. It is not yet clear from statistics that this can lead to a reduction in such rare, life-threatening complications. Mainly to patients who had a history of contrast allergy and allergy using non-ionic, low permeability contrast agent can reduce the incidence of complications.