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脂质体已被广泛地应用于生物膜的模拟研究。为了提高脂质体的结构稳定性,八十年代出现了聚合型的脂质体。这类脂质体实质上是聚合物微囊,它们结构稳定,但脂质体膜的流动性大大降低,而膜的流动性是生物膜的基本特征。Kurihara与Fendler于l983年发现,用双棕榈酰磷脂酰胆碱与H_2C=CHC_6H_4NHCO(CH_2)_(16)N~+(C_(16)H_(33))(CH_3)_2Br~-在超声作用下制成脂质体后再使后者的不饱和键聚合,可以制得结构比较稳定而且脂质体膜具有流动性的磷脂——聚合物型脂质体。他们所用的具有聚合官能基的磷脂类似物的合成很麻烦。Fang与
Liposomes have been widely used in biofilm simulation studies. In the 1980s, polymeric liposomes emerged in order to improve the structural stability of liposomes. These liposomes are essentially polymer microcapsules that are structurally stable, but the fluidity of the liposomal membrane is greatly reduced, while the fluidity of the membrane is a fundamental feature of the biofilm. Kurihara and Fendler appeared in l983 with dipalmitoylphosphatidylcholine and H_2C = CHC_6H_4NHCO (CH_2) _ (16) N ~ + (C_ (16) H_ (33)) (CH_3) _2Br ~ After the liposomes are made into the liposomes, the unsaturated bond of the latter is polymerized to obtain the phospholipid-polymer type liposomes with relatively stable structure and fluidity of the liposome membrane. The synthesis of phospholipid analogues with polymerized functional groups they use is cumbersome. Fang and