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目的:研究复方石栗喷雾剂的抗炎、镇痛作用。方法:采用小鼠耳廓肿胀法、大鼠足趾肿胀法、热板致痛法和小鼠扭体法研究复方石栗喷雾剂的抗炎、镇痛作用。结果:抗炎试验表明,高、中剂量复方石栗喷雾剂能显著降低由二甲苯所致试验小鼠耳廓的肿胀程度(P<0.01)和抑制由角叉菜胶溶液引起的试验大鼠足跖肿胀(P<0.01),显示出很好的抗炎作用;镇痛试验表明,高、中剂量复方石栗喷雾剂能显著增加热板法试验小鼠的痛阈值(P<0.05或P<0.01),减轻醋酸对试验小鼠内脏所致的疼痛(P<0.05或P<0.01),显示出较强的镇痛作用。结论:复方石栗喷雾剂有明显的抗炎、镇痛作用,且与剂量有一定关系,其镇痛作用机理可能与其缓解外周神经的紧张有关,与其抑制炎性介质渗出的关系有待进一步研究。
Objective: To study the anti-inflammatory and analgesic effects of Compound Shijili Spray. Methods: Anti-inflammatory and analgesic effects of Compound Shijia Spray were studied by auricle swollen method, rat’s toe swelling method, hot plate pain method and writhing method. RESULTS: The anti-inflammatory test showed that high and medium dose compound Shijitao spray can significantly reduce the swelling of the auricle of mice induced by xylene (P <0.01) and inhibit the rat foot caused by carrageenan solution (P <0.01), showing a good anti-inflammatory effect; analgesic test showed that the high and medium dose compound Shi Li spray can significantly increase the pain threshold of hot-plate test mice (P <0.05 or P <0.01 ), Relieved acetic acid on the visceral pain induced by the test mice (P <0.05 or P <0.01), showing a strong analgesic effect. Conclusion: The compound Shilu Spray has significant anti-inflammatory and analgesic effects, and has a certain relationship with the dose. The analgesic mechanism may be related to the alleviation of the peripheral nervous system tension, and its relationship with the inhibition of exudative inflammatory mediators remains to be further studied.