多形核白细胞在感染过程中具有吞噬作用,并发生代谢的改变,这可以通过多形核白细胞对四唑氮蓝(Nitroblue tetrazolium,NBT)染料还原能力的增强而得到证明。Park等人用这种试验作为鉴别细菌性疾病与非细菌性疾病的有用的辅助诊断方法。后者NBT试验为阴性。在儿童的慢性肉芽肿疾病中,NBT试验也为阴性。这是由于中性白细胞的功能障碍,不能消化入侵的微生物。后来, Polymorphonuclear leukocytes have phagocytosis during infection and undergo metabolic changes, as evidenced by the enhanced ability of polymorphonuclear leukocytes to reduce the capacity of the dye of Nitroblue tetrazolium (NBT). Park et al. Used this test as a useful adjunct to identifying bacterial and non-bacterial diseases. The latter NBT test is negative. In children with chronic granulomatous disease, the NBT test is also negative. This is due to the dysfunction of neutrophils that can not digest invading microorganisms. later,