论文部分内容阅读
目的研究并探讨头孢菌素类抗生素所致不良反应的发生情况及发生规律,为临床合理应用头孢菌素类抗生素提供借鉴和帮助。方法收集鹤岗鹤矿医院2016年1-12月期间上报的18例因使用头孢菌素类抗生素而致不良反应的病例报告,对病历资料进行回顾性研究、分析、总结。结果头孢菌素类抗生素所致不良反应的性别分布较为均匀,各年龄段均有分布,10岁以下儿童占比最高;给药途径以静脉滴注为主;涉及头孢菌素类抗生素的种类共有5种;不良反应累及器官主要为皮肤、消化系统,临床表现主要为过敏反应;转归方面,18例患者的不良反应在及时停药后均明显好转,未出现任何后遗症。结论临床在使用头孢菌素类抗生素时,应严格掌握药物配伍禁忌证,加强不良反应监测,以促进头孢菌素类抗生素的临床合理使用,减少药物不良反应,巩固治疗效果。
Objective To study and investigate the incidence and occurrence of adverse reactions caused by cephalosporin antibiotics and to provide reference and help for the rational application of cephalosporin antibiotics. Methods A total of 18 case reports of adverse reactions caused by cephalosporin antibiotics reported during January to December, 2016 in Hegang Crane Mining Hospital were collected. The medical records were retrospectively analyzed, analyzed and summarized. Results The sex distribution of adverse reactions caused by cephalosporin antibiotics was relatively uniform and distributed in all age groups, with the highest proportion of children under 10 years of age. The main route of administration was intravenous drip. The types of cephalosporin-containing antibiotics 5 kinds of adverse reactions involving the main organs of the skin, digestive system, the main clinical manifestations of allergic reactions; prognosis, 18 patients with adverse reactions were promptly discontinued after significant improvement without any sequelae. Conclusion In clinical use of cephalosporins antibiotics, drug compatibility contraindications should be strictly controlled and monitoring of adverse reactions should be strengthened in order to promote the clinical rational use of cephalosporin antibiotics, reduce the adverse drug reactions and consolidate the therapeutic effect.