Highly active CNT-promoted co-precipitated Cu-ZnO-Al2O3 catalysts, symbolized as CuiZnj;Alfc-a;%CNTs, were prepared, and their catalytic activity for once-through methanol synthesis from syngas was investigated. The results illustrated that, under the reaction conditions (at 493 K, 5.0 MPa, the volume ratio of H2/CO/CO2/N2= 62/30/5/3, GHSV= 4000 h-1), the observed single-pass CO-conversion and methanol-STY over a Cu6Zn3Al1-12.5%CNTs catalyst reached 64% and 1210 mg/(h-g), which was about 68% and 66% higher than those (38% and 730 mg/(h-g)) over the corresponding CNT-free catalyst, Cu6Zn3Al1, respectively. The characteristic studies of the catalysts revealed that appropriate incorporation of a minor amount of the CNTs into the CuiZnjAlk brought about little change in the apparent activation energy of the methanol synthesis reaction, however, led to a considerable increase in the catalyst’s active Cu surface area and pronouncedly enhanced the stationary-state concentration of active hydrogen-adspecies on Highly active CNT-promoted co-precipitated Cu-ZnO-Al2O3 catalysts, symbolized as CuiZnj; Alfc-a;% CNTs, were prepared, and their catalytic activity for once-through methanol synthesis from syngas was investigated. The results illustrated that, under the reaction conditions at 493 K, 5.0 MPa, the volume ratio of H2 / CO / CO2 / N2 = 62/30/5/3, GHSV = 4000 h- 1, the observed single-pass CO- conversion and methanol- STY over a Cu6Zn3Al1-12.5% ​​CNTs catalyst reached 64% and 1210 mg / (hg), which was about 68% and 66% higher than those (38% and 730 mg / (hg) Cu6Zn3Al1, respectively. The characteristic studies of the catalysts revealed that appropriate incorporation of a minor amount of the CNTs into the CuiZnjAlk brings about little change in the apparent activation energy of the methanol synthesis reaction, however, led to a substantial increase in the catalyst’s active Cu surface area and pronouncedly enhanced the stationary-state concentration of active hydr ogen-adspecies on