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１９９４年流感病毒Ｈ３Ｎ２亚型ＨＡ１基因核苷酸序列分析结果显示，经过２６年进化，共有１１４个核苷酸置换，引起５１个氨基酸变异，变异比例为１５．５％。自１９６８年＂香港流感＂引起人类暴发流行以来，ＨＡ１基因核苷酸置换率４～６个／每年，氨基酸变异２～３个／每年，核苷酸和氨基酸变异速度减慢。１９９４年三株病毒中，广东地区毒株比仙台地区和河北地区毒株多变异２～３个氨基酸；这从分子流行病学角度提示，广东地区流行毒株在目前流感病毒Ｈ３Ｎ２亚型的变异和流行中可能具有重要作用。
Analysis of nucleotide sequence of HA1 gene of influenza virus H3N2 subtype in 1994 showed that after 26 years of evolution, a total of 114 nucleotide substitutions resulted in 51 amino acid variations with a variance of 15.5%. Since 1968, “Hong Kong flu” caused a human outbreak, HA1 gene nucleotide replacement rate of 4 to 6 / year, amino acid variation of 2 to 3 / year, nucleotide and amino acid variation slowed down. Among the three viruses in 1994, the strains in Guangdong Province varied 2 to 3 amino acids more than the strains in Sendai and Hebei Provinces. From the point of view of molecular epidemiology, it was suggested that the prevalence of influenza virus H3N2 subtype in Guangdong And popular may have an important role.