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目的:观察肺心胶囊对慢性肺源性心脏病(CPHD)患者白介素8(IL-8)、肿瘤坏死因子α(TNF-α)的影响。方法:将120例患者随机分为2组,对照组予以西医常规治疗;治疗组在对照组基础上加服肺心胶囊治疗。2月后观测白细胞总数及分类计数,测定患者血清中IL-8、TNF-α的含量。结果:2组治疗后白细胞及分类计数均有明显改善,与治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01),2组治疗后白细胞总数及分类计数比较,差异有显著性意义(P<0.05)。2组治疗后IL-8、TNF-α水平,与治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01),治疗组IL-8、TNF-α水平显著下降,与对照组比较,差异有显著性意义(P<0.05)。结论:肺心胶囊能抑制炎性细胞的趋化和释放,减轻炎症和损伤,防止CPHD的发生。
Objective: To observe the effects of Feixin Capsule on interleukin 8 (IL-8) and tumor necrosis factor-α (TNF-α) in patients with chronic cor pulmonale (CPHD). Methods: One hundred and twenty patients were randomly divided into two groups. The control group was treated routinely with Western medicine. The treatment group was treated with Fei Xin Capsule on the basis of the control group. After 2 months, the total number of leukocytes and their counts were determined. The levels of IL-8 and TNF-α in serum of patients were measured. Results: After treatment, leukocyte count and classification were significantly improved in both groups (P <0.05, P <0.01). Compared with the total number of leukocytes after treatment and the classification and counting, The difference was significant (P <0.05). The levels of IL-8 and TNF-α in the two groups were significantly different from those before treatment (P <0.05, P <0.01). The levels of IL-8 and TNF-α in the two groups were significantly decreased Compared with the control group, the difference was significant (P <0.05). Conclusion: Feixin Capsule can inhibit chemotaxis and release of inflammatory cells, reduce inflammation and injury and prevent the occurrence of CPHD.