论文部分内容阅读
目的分析CD24和CD44在非小细胞肺癌组织中的分布,分析二者与非小细胞肺癌的关系。方法利用免疫组化法检测非小细胞肺癌13例癌旁组织与81例癌组织中CD24和CD44的表达。结果①在癌旁组织中CD24高表达,CD44则不表达;②51例(63%)患者癌组织中CD24表达阳性,55例(68%)CD44表达阳性,不同病理类型二者差异无统计学意义;③在非小细胞肺癌中,二者分布与病情相关。随肿瘤分化程度降低和临床分期升高CD24低表达者增多(P<0.05),肺腺癌中CD44分布规律与CD24相同,但肺鳞癌中CD44高表达者增多(P<0.05);④CD24与CD44在肺鳞癌中的表达呈负相关(P<0.05)。结论 CD24和CD44与非小细胞肺癌的发生、发展有关,为提高患者生存率和生活质量提供新的治疗靶点。
Objective To analyze the distribution of CD24 and CD44 in non-small cell lung cancer (NSCLC) and to analyze their relationship with non-small cell lung cancer (NSCLC). Methods The expression of CD24 and CD44 in 13 cases of paracancerous tissues and 81 cases of non-small cell lung cancer tissues were detected by immunohistochemistry. Results (1) CD24 was highly expressed in adjacent tissues and CD44 was not expressed; (2) CD44 was positive in 55 cases (68%) in 51 cases (63%), and no significant difference was found in different pathological types ; ③ in non-small cell lung cancer, the two are related to the distribution of the disease. (P <0.05). The distribution of CD44 in lung adenocarcinoma was the same as that of CD24, but the expression of CD44 in lung squamous cell carcinoma was increased (P <0.05) .④CD24 and The expression of CD44 in lung squamous cell carcinoma was negatively correlated (P <0.05). Conclusion CD24 and CD44 are associated with the occurrence and development of non-small cell lung cancer and provide new therapeutic targets for improving the survival rate and quality of life.