患者女,22岁。汉族,在内蒙高氟区居住18年。15岁开始,牙遇冷、热、酸、甜均感酸痛,并伴有齿龈出血。16岁开始,走路过多或久坐即感腰背酸痛。近3年,症状加剧,并伴关节疼痛。牙痛、倦怠、失眠、全身大小关节和肌肉疼痛逐日加重。后背、腰有时有蚁走感,并有排尿费力、大小便障碍。1989年10月因高热、恶寒、全身酸痛等症状恶化而住院治疗。其父、母、兄妹6人均有氟斑牙,其母、二哥有关节 Female patient, 22 years old. Han nationality, living in Inner Mongolia high fluoride area for 18 years. At the age of 15, teeth are cold, hot, sour and sweet with painful gums and gum bleeding. 16 years old, walking too much or sedentary feel back pain. Nearly 3 years, the symptoms intensified, and accompanied by joint pain. Toothache, fatigue, insomnia, body size joints and muscle pain increased day by day. Back, sometimes ants feel away from the waist, and urination laborious, urinary disorders. October 1989 due to high fever, aversion to cold, body aches and other symptoms of deterioration and hospitalization. The parent, mother, brother and sister six people have dental fluorosis, the mother, brother of the section