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目的：通过比较妇科肿瘤患者纤维连结蛋白（ＦＮ）的变化，评价ＦＮ对妇科肿瘤诊断及疗效评价的意义。方法：检测妇科良性肿瘤２６例、恶性肿瘤７１例治疗前后血浆的ＦＮ值，并与健康献血员４０例血浆ＦＮ值作对照。结果：妇科恶性肿瘤组治疗前血浆ＦＮ平均值为４．５０×１０－３±１．９０×１０－３ｍｍｏｌ／Ｌ，治疗后升至６．８１×１０－３±２．２２×１０－３ｍｍｏｌ／Ｌ，治疗前后差异有显著性（Ｐ＜０．０１）。恶性肿瘤组治疗前血浆ＦＮ值与健康献血员、良性肿瘤组治疗前血浆ＦＮ值比较差异也有显著性（Ｐ＜０．０１）。结论：妇科恶性肿瘤患者血浆ＦＮ值明显低于正常，治疗效果好的患者血浆ＦＮ值总的趋势是逐渐上升，治疗效果不好的患者血浆ＦＮ值总的趋势是逐渐下降。ＦＮ可作为妇科常见恶性肿瘤诊断、疗效观察的临床参考指标。
Objective: To evaluate the significance of FN in the diagnosis and evaluation of gynecological tumors by comparing the changes of fibronectin (FN) in patients with gynecologic oncology. Methods: FN values of 26 gynecological benign tumors and 71 malignant tumors were measured before and after treatment, and compared with the plasma FN of 40 healthy donors. Results: The average plasma FN in the gynecological malignant tumor group before treatment was 4.50 × 10-3 ± 1.90 × 10-3mmol / L, after treatment, it increased to 6.81 × 10-3 ± 2.22 × 10-3mmol / L, the difference was significant before and after treatment (P <0.01). There were also significant differences in plasma FN values before treatment between malignant tumor group and healthy blood donors and benign tumor group before treatment (P <0.01). Conclusion: The FN value of patients with gynecologic malignancies was significantly lower than that of normal patients. The overall trend of FN in patients with good prognosis was gradually increasing. The overall trend of FN in patients with poor prognosis was decreasing gradually. FN can be used as a common gynecological cancer diagnosis, the clinical observation of the clinical reference index.