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背景:众多研究表明C反应蛋白(C-reactiveprotein,CRP)对心肌梗死患者预后有很高的判定价值,但对缺血性脑卒中预后判定是否有同样的价值目前尚无定论。目的:探讨和比较CRP和纤维蛋白原(fibrinogen,FIB)对脑梗死预后判定的价值。设计:以诊断为依据,病例对照研究。地点和对象:全部患者均来自兰州医学院第二附属医院神经内科,94例脑梗死患者,男58例,女36例,平均年龄(58±11)岁。干预:采用免疫浊度法测定空腹状态下血浆中CRP和FIB水平,试剂盒由福建太阳生物技术公司提供,发病后3d评估患者的神经功能缺失评分,随访3个月统计脑梗死患者的残疾率、病死率。主要观察指标:脑梗死患者神经功能缺失评分、残疾率、病死率。结果:根据血中CRP水平,将脑梗死患者分为高CRP组和低CRP组;根据血中FIB水平,将脑梗死患者分为高FIB组和低FIB组。高CRP组脑梗死患者神经功能缺失评分(18.12±8.96)分,残疾率74%(40/54),病死率20%(11/54);低CRP组分别为(10.52±4.42)分,38%(15/40),5%(2/40)。高CRP组显著高于低CRP组t=3.82,χ2=12.66,4.56,P<0.001)(。高FIB组脑梗死患者神经功能缺失评分(17.69±5.12)分,残疾率70%(35/50);低FIB组分别为(14.32±4.65)分,45%(20/44),高FIB组显著高于低FIB组(t=2.19,χ=7.1,P<0.001),而病死率差异却无
BACKGROUND: Many studies have shown that C-reactive protein (CRP) has a high value in predicting the prognosis of patients with myocardial infarction. However, it is still not yet known whether CRP has the same value in predicting the prognosis of ischemic stroke. Objective: To investigate and compare the value of CRP and fibrinogen (FIB) in predicting the prognosis of cerebral infarction. Design: Based on diagnosis, case-control study. Location and Subjects: All patients were from Department of Neurology, the Second Affiliated Hospital of Lanzhou Medical College. Among 94 patients with cerebral infarction, 58 were male and 36 were female, with an average age of (58 ± 11) years. Intervention: To determine the plasma levels of CRP and FIB in the fasting state by the immunoturbidimetry method. The kit was provided by Fujian Sun Biotech Co., Ltd. The neurological deficit score was evaluated 3d after the onset of disease. The rate of disability in the patients with cerebral infarction was followed up for 3 months , Fatality rate. MAIN OUTCOME MEASURES: Neurological deficit score, disability rate, and mortality in patients with cerebral infarction. According to the levels of CRP in blood, patients with cerebral infarction were divided into high CRP group and low CRP group. According to the level of FIB in blood, patients with cerebral infarction were divided into high FIB group and low FIB group. The patients with high CRP had a neurological deficit score of 18.12 ± 8.96, a disability rate of 74% (40/54) and a case fatality rate of 20% (11/54), while those in the low CRP group were (10.52 ± 4.42), 38 % (15/40), 5% (2/40). The high CRP group was significantly higher than that in the low CRP group (t = 3.82, χ2 = 12.66, 4.56, P <0.001). The score of neurological deficit in patients with high FIB group was 17.69 ± 5.12 and the disability rate was 70% (14.32 ± 4.65), 45% (20/44) respectively in the low FIB group and significantly higher in the high FIB group than in the low FIB group (t = 2.19, χ = 7.1, P <0.001) no