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间质性膀胱炎(IC)是临床上一种较少见的疾病,其发病率无确切统计,以尿频、排尿困难,下腹部及尿道的疼痛为主要临床表现,女性多见。一、病因及病原学其病因不甚清楚,最近几年越来越多的研究表明本病系一自身免疫性疾病,因在某些IC病人身上用免疫学方法可查到抗膀胱粘膜的抗体,而在细菌性膀胱炎中并没有发现。Mattila于1983年在20例IC中发现70％病人出现见于自身免疫性疾病的典型血管内皮改变。Parviar也指出,IC与其它自身免疫性疾病有某些共同特点,如多发于女性(90％),常伴有SLE,类风湿性关节炎,结节性多动脉炎,硬皮病及自身免疫性甲状腺炎等。
Interstitial cystitis (IC) is a clinically rare disease, the incidence of no exact statistics, frequent urination, dysuria, lower abdominal and urethral pain as the main clinical manifestations, more common in women. First, the etiology and etiology The etiology is not clear, in recent years, more and more studies show that the disease is an autoimmune disease, because in some IC patients with immunological methods can be found anti-bladder mucosal antibodies , But not found in bacterial cystitis. In 1983, Mattila found that 70% of patients in 20 IC showed typical changes of vascular endothelium found in autoimmune diseases. Parviar also noted that ICs have some common features with other autoimmune diseases such as multiple women (90%), often with SLE, rheumatoid arthritis, polyarteritis nodosum, scleroderma and autoimmunity Sexual thyroiditis and so on.