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目的:研究EphB4、ERα和ERβ等各自的蛋白在子宫内膜癌(EC)中的表达及意义。方法:用SP法检测71例EC组织中EphB4、ERα和ERβ等各自蛋白的表达水平。结果:EphB4、ERα和ERβ的蛋白在71例EC组织中表达的阳性率分别为69.3%、52.3%和60.6%。EC组织中EphB4蛋白的阳性率与组织学分级、淋巴结转移、临床分期和年龄显著相关(P<0.05),ERα蛋白表达的阳性率与EC的淋巴结转移、病理类型、组织学分级和临床分期显著相关(P<0.05),ERβ蛋白的阳性率与淋巴结转移显著相关(P<0.05)。EphB4蛋白的阳性率与ERα、ERβ蛋白的阳性率均显著相关(P<0.05)。结论:EphB4、ERα和ERβ可能与EC的发生、发展有关,联合检测对EC的生物学行为的客观评估可提供帮助,可用来指导临床治疗和预测预后。
Objective: To study the expression and significance of EphB4, ERα and ERβ in endometrial carcinoma (EC). Methods: The expressions of EphB4, ERα and ERβ in 71 EC tissues were detected by SP method. Results: The positive rates of EphB4, ERα and ERβ in 71 EC tissues were 69.3%, 52.3% and 60.6% respectively. The positive rate of EphB4 protein in EC tissues was significantly correlated with histological grade, lymph node metastasis, clinical stage and age (P <0.05). The positive rate of ERα protein expression was correlated with lymph node metastasis, pathological type, histological grade and clinical stage of EC (P <0.05). The positive rate of ERβ protein was significantly correlated with lymph node metastasis (P <0.05). The positive rate of EphB4 protein was significantly correlated with the positive rate of ERα and ERβ (P <0.05). Conclusion: EphB4, ERα and ERβ may be related to the occurrence and development of EC. Combined testing can help to objectively evaluate the biological behavior of EC and can be used to guide the clinical treatment and predict the prognosis.