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目的 探讨双黄连注射液对乌头碱中毒所致心律失常的治疗作用。方法 将 6 0例重度乌头碱中毒患者随机分成治疗组和对照组。对照组按常规给予洗胃或催吐、导泻、镇静、输液、抗心律失常、治疗低血压等 ;治疗组 (不洗胃或催吐 ,亦不导泻 )首先给予双黄连注射液滴注 ,然后输液。结果 ①治疗组疗效明显优于对照组 (P <0 0 1) ;②心律失常恢复时间 ,治疗组早搏及房颤在 15min内全部恢复 ,窦性心动过缓在 12h内恢复 ;对照组恢复时间则在 2 4h以上 (P <0 0 1) ;③两组临床症状改善时间 :治疗组平均 (2 5 2± 9 7)min ;对照组平均 (176 4 1± 6 6 4 35 )min。低血压改善时间 :治疗组在 30min内恢复正常 ;对照组时间均在 2 7h(16 2 0min)以上 ,(P <0 0 1)。结论 双黄连注射液对乌头碱中毒所致心律失常有特效治疗作用。
Objective To investigate the therapeutic effect of Shuanghuanglian injection on arrhythmia caused by aconitine poisoning. Methods Sixty patients with severe aconitine poisoning were randomly divided into treatment group and control group. The control group was given gastric lavage or vomiting, catharsis, sedation, infusion, anti-arrhythmia, treatment of hypotension, etc .; the treatment group (not gastric lavage or vomiting, nor catharsis) first Shuanghuanglian injection instillation, and then Infusion. Results ① The curative effect in the treatment group was significantly better than that in the control group (P <0.01); ② The recovery time of arrhythmia, the recovery of premature beat and atrial fibrillation in the treatment group were all recovered within 15 minutes; the sinus bradycardia recovered within 12 hours; (P <0.01); ③The improvement of clinical symptoms in the two groups was (2 5 2 ± 9 7) min in the treatment group and 176 4 1 ± 6 6 4 35 min in the control group. Hypotension time: The treatment group returned to normal within 30 minutes; the control group was above 27h (1620min) (P <0.01). Conclusion Shuanghuanglian injection on aconitine poisoning caused by arrhythmia treatment effect.