目的　比较国产盐酸托烷司琼和进口盐酸托烷司琼在控制由顺铂化疗所致食欲减退、恶心、呕吐反应的疗效和安全性。方法　采用随机、双盲对照方法对 48例接受含顺铂化疗的恶性肿瘤患者进行研究。于化疗前 1d开始给予国产盐酸托烷司琼或进口盐酸托烷司琼 ,1次 d ,5mg 次 ,连用 6d ,同时观察并记录患者食欲减退、恶心、呕吐反应及其他不良反应。结果　入选患者全部按试验要求完成现察 ,国产盐酸托烷司琼与进口盐酸托烷司琼在控制食欲减退、恶心、呕吐反应方面及发生其它不良反应方面均无显著性差异 (P >0 .0 5 )。结论　国产盐酸托烷司琼在控制含顺铂化疗所致食欲减退、恶心、呕吐反应的疗效和用药安全性与进口盐酸托烷司琼相当。 Objective To compare the efficacy and safety of domestic tropisetron and imported tropisetron hydrochloride in the control of anorexia, nausea and vomiting induced by cisplatin chemotherapy. Methods A randomized, double-blind, controlled trial of 48 patients with malignant tumors treated with cisplatin was performed. One to five days before chemotherapy, patients were given domestic tropicone or imported tropisetron once or d for 5 days, and then used for 6 days. At the same time, patients’ appetite, nausea, vomiting and other adverse reactions were observed and recorded. Results All patients were selected according to the requirements of the trial. Domestic tropoxifen hydrochloride and imported tropisetron hydrochloride showed no significant difference in controlling loss of appetite, nausea, vomiting and other adverse reactions (P> 0. 0 5). Conclusion Tropisetron Hydrochloride in the control of cisplatin-induced loss of appetite, nausea and vomiting response and drug safety and import of tropisetron hydrochloride equivalent.