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以前的研究推荐罗氏芬的用药量为每日1~2g,但在治疗成人呼吸道感染方面何为适当剂量尚不十分清楚,对药物经济学而言,剂量的减少不应影响到疗效,因此本文采用随机分组,对罗氏芬1g每日一次与头孢氨噻肟1g每日三次静脉给药前瞻性随机对照治疗74例下呼吸道感染的疗效与安全性作了比较.两个药物均为第三代头孢菌素,具有高度抗菌活性,对β-内酰胺酶高度稳定.两者的抗菌谱基本相同,但其药物动力学特性具显著差异.罗氏芬的排除半衰期是8h,24h以后血内所含活性物质的浓度也高于主要病原体最低抑菌浓度数倍,每天仅须一次给药.而头孢氨噻肟的消除较快(半衰期仅1h)故每天必须数次给药.结果显示两组疗效相仿,临床治愈率分别在73．0%,70．3%,总有效率均为91. 9%,两治疗组间在其它观察指标如临床症状或退热时间中位数、细菌清除率也无显著差异.所有患者对两种抗菌素的耐受性均良好,无严重的不良反应.总之,这一随机性的研究提示罗氏芬每日一次1g给药的优越性可充分利用.
The previous study recommended that Rofenfen should be administered in an amount of 1 to 2 g daily, but it is not yet clear what the appropriate dose is in treating adult respiratory infections. In the case of pharmacoeconomics, the dose reduction should not affect the efficacy. Therefore, A randomized, prospective, randomized controlled trial of 74 patients with lower respiratory tract infection with 1 g of Rocephin once daily and 1 g of cefotaxime administered intravenously per day was compared for efficacy and safety. Both drugs were of the third generation Cephalosporin has a high degree of antibacterial activity and is highly stable to β-lactamase.The antimicrobial spectrum of the two cephalosporins is basically the same, but its pharmacokinetic properties are significantly different.The half-life of Rocephin is 8h and 24h The active substance concentration is also several times higher than the minimum inhibitory concentration of the main pathogen, only once a day, while cefotaxime elimination is faster (half-life of only 1h) and therefore must be administered several times a day. Similarly, the clinical cure rates were 73.0%, 70.3%, the total effective rate was 91.9%, the two treatment groups in other indicators such as clinical symptoms or the median time of fever, bacterial clearance rate No significant difference between all patients Tolerance kinds of antibiotics were good, no serious adverse reactions. In summary, this study suggests that the randomness of Rocephin once daily administration of 1g of superiority can be fully utilized.