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代谢组学是对某一生物或细胞所有低相对分子质量代谢产物进行定性和定量分析的一门新学科,由于其应用前景广泛,目前已成为系统生物学的重要组成部分。采用代谢组学技术发现慢性温和不可预知应激(CUMS)模型诱导的抑郁症病理机制与多种内源性代谢物有关,按化学类别该内源性代谢物可以分为氨基酸、脂肪酸、糖类、核苷酸、脂蛋白、N-乙酰糖蛋白、苯丙乙酰甘氨酸、胆碱、胆酸、溶血磷脂酰胆碱等物质;按代谢途径可以分为氨基酸代谢、能量代谢、肠微生物代谢、酮体代谢等途径。抑郁症病理机制不是某个代谢途径异常或某个特定区域单独受到扰动的结果,而是多个代谢途径异常或者多个区域的联合效应。对基于代谢组学技术分析CUMS诱导的抑郁症发病机制的研究进展进行综述。
Metabolomics is a new discipline for the qualitative and quantitative analysis of all low molecular weight metabolites of a given organism or cell. Due to its wide range of applications, metabolomics have become an important part of system biology. The use of metabonomics techniques to discover chronic myelogenous unpredictable stress (CUMS) -induced pathological mechanisms of depression associated with a variety of endogenous metabolites, the chemical class of the endogenous metabolites can be divided into amino acids, fatty acids, carbohydrates , Nucleotides, lipoproteins, N-acetyl glycoprotein, phenylpropionyl glycine, choline, cholic acid, lysophosphatidylcholine and other substances; by metabolic pathways can be divided into amino acid metabolism, energy metabolism, intestinal microbial metabolism, ketones Body metabolism and other means. The pathological mechanism of depression is not the result of an abnormal metabolic pathway or disturbance of a specific region alone, but rather the combination of multiple metabolic pathways or multiple regions. The progress of the research on the pathogenesis of CUMS-induced depression based on metabonomics was reviewed.