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目的了解母亲感染丝虫后，对其婴幼儿免疫应答会产生怎样关系及导致何种结局。方法用抗牛丝虫多抗ＥＬＩＳＡ双抗体夹心法与马来丝虫成虫切片抗原免疫酶染色技术（ＩＥＳＴ）分别检测淮北班氏丝虫流行区微丝蚴（ｍｆ）阳性、阴性的母亲及其１～１０岁子女、产妇及其婴儿血清中丝虫循环抗原（ＦＣＡｇ）与ＩｇＭ抗体。另对细胞免疫等作了检测。结果在５４例ＦＣＡｇ阳性产妇中有３３例其婴儿亦为阳性，二者符合率为６１．１％。乳汁４份ＦＣＡｇ皆阳性。ｍｆ阳性产妇及其婴儿血ＩｇＭ阳性率分别为７０．８％（１７／２４）和８．３％（２／２４），ｍｆ阴性组的分别为１０．６％（１０／９４）和３．２％（３／９４），其二组婴儿血ＩｇＭ水平经χ２检验差异无显著意义（Ｐ＞０．０５）。结论提示ＦＣＡｇ能经胎盘进入胎儿体内。从ＩｇＭ水平看，母亲感染丝虫与否，对其子代先天免疫耐受的产生和抗感染均无明显影响。
Objective To understand the relationship between infants and young children’s immune response and the resulting outcomes after the mother was infected with filarial worms. Methods The positive and negative mf-positive and negative mf-positive and negative mothers in the prevalence area of Bancroftian filarial in Huaibei were detected by sandwich ELISA with double antibody sandwich ELISA and Ise immunohistochemical staining (IEST) 1 to 10 years old children, maternal and infant serum filarial circulating antigen (FCAg) and IgM antibodies. The other on cellular immunity and other tests. Results Of the 54 FCAg-positive mothers, 33 infants were also positive, with a coincidence rate of 61.1%. Four copies of milk FCAg are positive. The positive rates of IgM in mf positive mothers and their infants were 70.8% (17/24) and 8.3% (2/24) respectively, while those in mf negative group were 10.6% (10/94) and 3, respectively. 2% (3/94). There was no significant difference in IgM level between the two groups (χ2 test) (P> 0.05). Conclusions FCAG can enter the fetus through the placenta. From the IgM level, the mother of filariasis or not, on their offspring innate immune tolerance and anti-infection had no significant effect.