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人类免疫细胞和炎症细胞可以产生一种粒细胞集落刺激因子(G-CSF)。这种因子是一种分子量为20000的糖蛋白,对嗜中性粒细胞有许多重要作用。G-CSF 能刺激骨髓中不成熟的细胞,使其增殖和分化成粒细胞,也能使成熟的粒细胞延长存活期,并能增强其ADCC 效应,促进其趋化因子的结合,加强其吞噬作用,是决定免疫和炎症反应区中性粒细胞数量和功能活性的一个主要细胞因子。已知多种细胞能产生G-CSF,但单核-
Human immune cells and inflammatory cells can produce a granulocyte colony stimulating factor (G-CSF). This factor is a glycoprotein with a molecular weight of 20,000, which has many important effects on neutrophils. G-CSF stimulates immature cells in the bone marrow to proliferate and differentiate into granulocytes and also prolong the survival of mature granulocytes and enhance their ADCC effects, promote their chemokine binding, and enhance their phagocytosis Is a major cytokine that determines the number and functional activity of neutrophils in the immune and inflammatory response areas. A variety of cells are known to produce G-CSF, but mononuclear-