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Objective: To study the influence of T-suppressor cell activity on habitual abortion (HA) and to observe the regulatory effect of Yangxue Antai Granule (YXATG) on T-suppressor cell and its effect on fetus preservation. Methods: T-suppressor cell activities of 56 pregnant women with H A history were tested with method of short life T-suppressor cell activity (MTT method) during early pregnancy, and were followed-up in middle and late pregna ncy in 20 cases of them. All the 56 patients YXATG treatment. Groups of normal early pregnant, normal non-pregnant women and those non-pregnant but with history of habitual abortion were involv ed in this study as control. Results: T-suppressor cell activity in early pregnancy was lowe r than that of middle and late pregnancy (P<0.01, P<0.001) and also low er than that of the control groups (P<0.01, P<0.001). The successful rate of fetus preservation of YXATG was 98.2%, and 98.0% of the cases got normal delivery. Conclusion: Low T-suppressor cell activity might be the immunologic etiology of HA. The fetus preservative effect of YXATG might be due to its regulatory effect on T-suppressor cell activity.