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常规放疗模式沿用多年,肿瘤治愈率难以得到大的突破。放疗总剂量与肿瘤预后直接相关,按照放射生物学推断的肿瘤治疗剂量明显高于目前常规放疗模式的放射总剂量。生物有效剂量与局控率和生存率有显著相关性,其提高依赖于单次剂量的提高。短疗程高分次剂量的放射治疗模式主要通过立体定向适形放疗实现。目前立体定向放射治疗装置单次放射剂量提高至4～8Gy,但是治疗精度无法进一步提高。射波刀在固定方式、实时位置验证、影像引导及动态追踪病灶等方面具有明显的技术优势,单次放射剂量能够提高至15～30Gy,成为短疗程单次高剂量放疗模式的最佳执行者,治疗效果更好。射波刀高分次剂量短疗程放疗模式本身在很多方面有待完善发展。
Conventional radiotherapy model used for many years, difficult to get a big breakthrough in tumor cure rate. The total dose of radiation therapy is directly related to the prognosis of the tumor, and the dose of tumor therapy inferred according to radiobiology is significantly higher than the total radiation dose of the conventional radiotherapy mode. There is a significant correlation between bioavailable dose and local control rate and survival rate, the improvement depends on the single dose increase. Short-course high-dose radiation therapy mode is mainly achieved by stereotactic conformal radiotherapy. The current stereotactic radiation therapy device single dose increased to 4 ~ 8Gy, but the accuracy of the treatment can not be further improved. The surgeon has obvious technical advantages in fixed mode, real-time position verification, image guidance and dynamic tracking of lesions, etc. The single dose can be increased to 15 ~ 30Gy and become the best performer in a single high-dose radiotherapy mode , The treatment effect is better. Radiation knife high-dose short course of radiation therapy model itself in many aspects to be perfect development.